Members

Current members:

Sara Alqudah – Graduate Student

Sara was born in Saudi Arabia to a Jordanian father and a Yemeni mother, she earned her bachelor’s degree in Medical Laboratory Sciences from Jordan University of Science and Technology (JUST) and was ranked the top of her class in 2013. She then started her academic career by working as a Teaching Assistant in the Medical Laboratory Sciences department while earning her master’s degree in Hematology and Blood Banking at JUST in 2016. Her master’s thesis was about investigating the dysregulation of the RANKL/RANK/OPG axis in thalassemia intermedia patients. In 2015, she worked as a full time Medical Lab Technician in the Pathology and Medical Laboratory department at King Abdullah University Hospital where she also trained students in advanced equipped medical laboratory techniques. She moved to Cleveland to start her PhD journey in 2021, studying Clinical Bioanalytical Chemistry at Cleveland State University, and after rotating in the Claesen Lab, she decided to join the lab, where she is working on the dietary effect of flavonoid metabolites in a diabetic mice model.

In her free time, Sara enjoys jogging, trying different kinds of food, listening to music, traveling, discovering new places, and spending time with her family and friends.

Jan Claesen – Principal Investigator

Jan was born and raised in Alken, a small town with a big brewery in Belgium. He obtained a B.S. and M.S. in Biological Engineering at the KU Leuven, Belgium, and specialized in Cell and Gene Biotechnology. Next, Jan joined the lab of Prof. Mervyn Bibb and he received his Ph.D. in Molecular Microbiology in 2011 from the John Innes Centre and University of East Anglia, Norwich, UK. His Ph.D. studies involved the genetics and biosynthesis of ribosomally synthesized and post-translationally modified peptide antibiotics in Streptomyces. After his graduate studies, Jan was a postdoctoral scholar in the lab of Dr. Michael Fischbach in the Department of Bioengineering and Therapeutic Sciences at the University of California, San Francisco, USA. There, his work focused on the characterization of bacterial metabolites that mediate microbe-microbe and microbe-host interactions in human gut and skin. The Claesen group was established at the Lerner Research Institute, Cleveland Clinic in November 2017. Our aim is to characterize the role of bioactive microbial and dietary small molecules in microbiota-associated diseases.

In his free time, Jan enjoys hiking, outdoors activities, cooking, traveling, RPG computer games, heavy and alternative music, Lego, and spending time with his wife and two daughters.

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Beckey DeLucia – Research Technician

Beckey joined the Claesen lab as a research technician in March of 2020 after completing her bachelor’s in biological sciences at the University of South Carolina. Beckey’s research is focused on the role of diet and gut microbial metabolites in the prevention of colorectal cancer. Something Beckey enjoys about being a part of the Claesen lab is the immense opportunities to work collaboratively with others. During her time in the lab she has had the joy of working with other labs within the LRI, the engineers located at the Cleveland clinic, and pathologists. She feels that because of these collaborative opportunities, the resources and support here are endless.

Outside of the lab, Beckey enjoys painting, finding record shops to expand her vinyl collection, and visiting her friends and family back in Rochester, NY.

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Rachel Markley – Postdoctoral Fellow

Rachel was born and raised in Harleysville, Pennsylvania, a suburb of Philadelphia. She obtained a B.S. in Biology and a B.A. in Fine Arts from Gettysburg College. She later went on to obtain a M.S. in Biotechnology from The Pennsylvania State University (Penn State). After a short interlude studying the proteomic profile of Chlamydia trachomatis at a pharmaceutical company she returned to Penn State to work in the lab of Dr. Girish Kirimanjeswara. While in the Kirimanjeswara lab, her work focused on the effects of dietary selenium on macrophage response to the intracellular bacteria Francisella tularensis. Rachel finished her Ph.D. in Immunology and Infectious Diseases in 2017. After completion of her graduate studies she moved to the Cleveland area where she is presently a postdoctoral fellow in the lab of Dr. Jan Claesen at Lerner Research Institute, Cleveland Clinic. She is currently studying the role of aryl polyenes, a product of a biosynthetic gene cluster (BCG) in Escherichia coli and other Gram-negative bacteria . Rachel is focused on gaining a better understanding of how aryl polyene expression influences bacterial colonization, immune response and resulting pathogenesis.

In her free time Rachel enjoys spending time with her family and dog hiking, gardening, cooking and traveling.

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Shreyaa Nagajothi – Undergraduate Student

Shreyaa Nagajothi was born in Detroit, Michigan and grew up in Canton, Ohio. She is currently a Chancellor’s scholar at the University of Pittsburgh majoring in neuroscience. Shreyaa’s first experience in research was with Dr. Mark Dahlman of Kent State University, studying the prevalence of MRSA in various fitness facilities. She started working with Dr. Jan Claesen at Cleveland Clinic in June of 2019. She is also a member of Dr. Udai Pandey’s lab at the University of Pittsburgh, which studies the molecular mechanisms of ALS pathogenesis.

In her free time, Shreyaa enjoys spending time with her friends and family and trying new restaurants in Pittsburgh.

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Luke Osborn – Postdoctoral Fellow

Luke was born in Ft. Collins, CO where he spent much of his childhood roaming the Rocky Mountains. In 2013, he obtained his B.S. in Biomedical Laboratory Diagnostics from Lyman Briggs College of Michigan State University. Luke then completed an internship at the Cleveland Clinic’s School of Medical Technology where he became a board-certified Medical Laboratory Scientist. He then worked in the Immunohematology and Clinical Microbiology labs at the Cleveland Clinic for several years before joining the Cleveland Clinic/Case Western Reserve University Molecular Medicine PhD program in 2017. After rotating in the labs of Mark Brown, Stanley Hazen, and Jan Claesen, Luke joined the Brown and Claesen labs, leveraging their experience in nutrition and microbiology, respectively, where he’s working on the microbial metabolism of dietary input in cardiometabolic disease.

In his free time, Luke enjoys spending time with his wife, dirt biking, traveling, and managing his small petting zoo of 2 cats, 2 dogs, and 4 chickens.

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Kelsey Ouyang – Medical Student

Kelsey Ouyang was born and raised in the Bay Area of California. She obtained her Bachelor’s degree in Human Biology and Society from the University of California, Los Angeles (UCLA). During her time at UCLA, she joined the lab of Dr. Jenny Kim, where she studied the role of Cutibacterium acnes (C. acnes) in the initiation and progression of the common skin disease acne vulgaris. After graduating, she worked at a digital healthcare start-up company before she returned to UCLA to work as a Staff Research Associate. Under the guidance and supervision of Dr. George Agak and Dr. Robert Modlin, she worked on elucidating the mechanisms by which C. acnes activate immune cells and instruct adaptive Th1 and Th17 cell responses in acne. She is now a first-year medical student at the Cleveland Clinic Lerner College of Medicine (CCLCM) and is conducting her summer basic research internship in Dr. Jan Claesen’s lab.

In her free time, she enjoys hiking, running, traveling, visiting coffee shops, and spending time with friends and family.

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Past members:

Karlee Schultz – Undergraduate Student – Current position: Medical Student at Ohio State University, Columbus, OH

Carter Powers – Medical Student (summer internship) – Current position: Medical Student at Cleveland Clinic Lerner College of Medicine, Cleveland, OH

Isabel Johnston – Postdoctoral Fellow – Current position: Postdoctoral Fellow in the McDonald lab, Lerner Research Institute, Cleveland, OH

BJ Massey – Rotation Graduate Student – Current position: Graduate Student in the Brown lab, Lerner Research Institute, Cleveland, OH

Jade Larney – Undergraduate Student – Current position: Leasing and Operations Manager at Equity Management, Youngstown, OH

Liz McManus – Undergraduate Student (summer internship) – Current position: Postbaccalaureate Fellow at National Cancer Institute, NIH, Bethesda, MD