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July 12, 2021: We’re welcoming Kelsey to or lab today. Kelsey is a first year med student in the Cleveland Clinic Lerner College of Medicine and for her Summer Basic Research Experience, she will be working with Rachel on unraveling the biological function of aryl polyenes.
July 2, 2021: Big congrats to Isabel! Her paper on “Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation” is published today in npj Biofilms and Microbiomes. Isabel’s study identifies essential genes within our model E. coli aryl polyene (APE) biosynthetic gene cluster, and characterizes two physiological roles for APEs as bacterial fitness factors. APE expression provides increased protection from oxidative stress and contributes to faster and more robust biofilm formation.
July 2, 2021: Today we’re saying goodbye to Karlee, an amazing undergrad student who helped out in several lab projects. Her cheerful presence in lab will be missed. While we’re sad to see her leave, we’re excited she’s going to med school and we expect she will become an awesome physician! Enjoy your well-deserved vacation Karlee.
June 15, 2021: Luke did an awesome job at his thesis defense! Congratulations Dr. Osborn!!! Afterwards the Claesen and Brown labs went out to celebrate Luke’s accomplishment with a Taco Tuesday dinner.
May 17, 2021: We’re welcoming Sara, who started her rotation in our lab today. Sara is a first year graduate student in the Clinical Bioanalytical Chemistry program at Cleveland State University.
May 10, 2021: Congratulations to Luke and Danny Orabi (Brown lab) on getting their manuscript on “A surgical method for continuous intraportal infusion of gut microbial metabolites in mice” published in JCI Insight. Danny developed a surgical technique for cannulation of the portal vein, which uses a mini pump implanted under the skin for continuous delivery of gut microbial metabolites. This method will be useful for functionally testing long-term effects of individual metabolites in mouse disease models.
April 1, 2021: We received the notice of award for the lab’s first R01! Many thanks to NIAID for supporting our plans to characterize the chemistry and biology of bacterial aryl polyene production.
March 11, 2021: Check out the updated preprint of Isabel’s paper on aryl polyene biosynthesis and role in biofilm formation.
January 18, 2021: Welcoming Rachel, a new Postdoctoral Fellow, to the team!
December 9, 2020: Congratulations to Luke for winning a Velosano Trainee Dream Experiment Fellowship!
December 4, 2020: We received a Jump Start pilot grant from the Case Comprehensive Cancer Center to study the role of the gut microbiome in modulating brain cancer development.
October 29, 2020: Danny Orabi (Brown lab) and Luke’s collaborative paper on intra-portal delivery of small molecules in mice has been posted on bioRxiv.